Thermo Fisher Scientific Factor XIII B Polyclonal Antibody
Human Factor XIII B에 특이적인 Rabbit Polyclonal Antibody로 Western blot 및 IHC(P) 검증됨. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 장기 보관 시 -20°C에서 보관. 연구용으로 혈액 응고 관련 단백질 분석에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Factor XIII B. Recombinant protein control fragment (Product #RP-100497) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641198 |
Product Specific Information
Immunogen sequence:
FCLAGYTTES GRQEEQTTCT TEGWSPEPRC FKKCTKPDLS NGYISDVKLL YKIQENMHYG CASGYKTTGG KDEEVVQCLS DGWSSQPTCR KEHETCLAPE LYNGNYSTTQ KTFKVKDKVQ YECATGYYTA GGKKTEEV
Antigen sequence identity:
- Mouse: 75%
- Rat: 79%
Target Information
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A and two B subunits. The A subunits have catalytic function, while the B subunits act as plasma carrier molecules without enzymatic activity.
Platelet factor XIII consists only of two A subunits, identical to those in plasma. Upon activation by thrombin cleavage and calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme factor XIIIa, which catalyzes γ-glutamyl-ε-lysine crosslinking between fibrin molecules to stabilize clots.
Factor XIII deficiency is classified as:
- Type I: Lack of both A and B subunits
- Type II: Lack of A subunit only
These defects can lead to lifelong bleeding tendencies, impaired wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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