Thermo Fisher Scientific Slc22a5 Polyclonal Antibody
Thermo Fisher Scientific의 Slc22a5 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot, IHC, ICC, ELISA에 사용 가능합니다. 단백질 A로 정제된 Rabbit IgG 항체로, 고순도 액상 형태이며 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Slc22a5 (amino acids 101–210) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the β-oxidation of long-chain fatty acids.
Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney.
Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells.
- OCTN1: Expressed in kidney, trachea, bone marrow, and fetal liver
- OCTN2: Abundantly expressed in kidney, skeletal muscle, placenta, and heart
- OCTN3: Strongly expressed in testis and weakly in kidney
Mutations in the gene encoding OCTN2 lead to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia, and hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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