Thermo Fisher Scientific AHR Monoclonal Antibody (3B12)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MGSFEPSPYP TTSSLEDFVT CLQLPENQKH GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH THVGQMQYNP VLPGQQAFLN KFQNGVLNET YPAELNNINN

Target Information

AHR (Ah Receptor) belongs to a family of proteins that includes its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM.
AHR contains an N-terminal PAS domain (~200 amino acids) and is found in various tissues. It binds specific DNA enhancer sequences and initiates transcription of the cytochrome P-450 (CYPIA1) gene.
AHR encodes a ligand-activated transcription factor regulating biological responses to planar aromatic hydrocarbons. It controls xenobiotic-metabolizing enzymes such as cytochrome P450, with ligands including polycyclic and halogenated aromatic compounds (e.g., TCDD).
In non-ligand activated cells, AHR is complexed with HSP90 in the cytoplasm. Upon activation, AHR translocates to the nucleus, forming a heterodimer with ARNT to bind DNA.
Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.