Thermo Fisher Scientific AHR Monoclonal Antibody (3B12)
AHR 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot, ICC/IF, ELISA, IP 등 다양한 응용에 적합. 인간 시료 반응성, 비결합형 액상 형태, PBS 버퍼에 보존. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
| Immunoprecipitation (IP) | 1–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B12 |
| Immunogen | AHR (NP_001612, 721–820 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MGSFEPSPYP TTSSLEDFVT CLQLPENQKH GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH THVGQMQYNP VLPGQQAFLN KFQNGVLNET YPAELNNINN
Target Information
AHR (Ah Receptor) belongs to a family of proteins that includes its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM.
AHR contains an N-terminal PAS domain (~200 amino acids) and is found in various tissues. It binds specific DNA enhancer sequences and initiates transcription of the cytochrome P-450 (CYPIA1) gene.
AHR encodes a ligand-activated transcription factor regulating biological responses to planar aromatic hydrocarbons. It controls xenobiotic-metabolizing enzymes such as cytochrome P450, with ligands including polycyclic and halogenated aromatic compounds (e.g., TCDD).
In non-ligand activated cells, AHR is complexed with HSP90 in the cytoplasm. Upon activation, AHR translocates to the nucleus, forming a heterodimer with ARNT to bind DNA.
Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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