Thermo Fisher Scientific 53BP2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human 53BP2. Recombinant protein control fragment (Product #RP-92050). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:53BP2,uniProtId:Q13625-1,ncbiNodeId:9606,antigenRange:587-693,antigenLength:1128,antigenImageFileName:PA5-54468_53BP2_Q13625-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54468_53BP2_Q13625-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2637497

Product Specific Information

Immunogen sequence: PQPSKDTLLP PFRKPQTVAA SSIYSMYTQQ QAPGKNFQQA VQSALTKTHT RGPHFSSVYG KPVIAAAQNQ QQHPENIYSN SQGKPGSPEP ETEPVSSVQE NHENERI

Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 90%.

Target Information

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.