Thermo Fisher Scientific Protein Z Polyclonal Antibody
Rabbit polyclonal antibody targeting Protein Z (PROZ), validated for WB and ELISA. Recognizes human, mouse, and rat species. Supplied as liquid, affinity purified, 2.48 mg/mL concentration. Suitable for research on coagulation pathways and vitamin K–de...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 220–340 of human PROZ (NP_003882.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913994 |
Product Specific Information
Positive test controls include: HepG2, 293T, Mouse kidney, Rat liver, Rat kidney.
Target localization: Secreted.
Immunogen sequence:
SLLHRNITVK TYFNRTSQDP LMIKITHVHV HMRYDADAGE NDLSLLELEW PIQCPGAGLP VCTPEKDFAE HLLIPRTRGL LSGWARNGTD LGNSLTTRPV TLVEGEECGQ VLNVTVTTRT Y
Target Information
Protein Z (PROZ) is a vitamin K–dependent plasma glycoprotein (~62 kDa, 396 amino acids) involved in the coagulation cascade. It contains four domains: a Gla-rich region, two EGF-like domains, and a trypsin-like domain. Although structurally related to serine proteases (factors VII, IX, X, and protein C), it lacks catalytic activity. Protein Z enhances the degradation of factor Xa by protein Z–related protease inhibitor (ZPI), accelerating the reaction up to 1000-fold. Deficiency has been variably associated with thrombosis or bleeding tendencies.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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