Thermo Fisher Scientific TCF7L2 Polyclonal Antibody
TCF7L2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, Flow Cytometry에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제, 1 mg/mL 농도. Wnt 신호전달 및 당대사 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within N-terminal Human TCF4 (amino acids 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% Glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802794 |
Target Information
TCF7L2 (also known as TCF4) is a high mobility group (HMG) box-containing transcription factor involved in the Wnt signaling pathway. It regulates pro-glucagon gene expression, influencing glucose homeostasis and GLP-1 production. Genetic variants of TCF7L2 are linked to type 2 diabetes and play a role in beta-cell survival and function. Multiple splicing isoforms are differentially expressed during cancer progression, and TCF7L2 is essential for maintaining small intestine crypt stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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