Thermo Fisher Scientific DOCK11 Polyclonal Antibody
DOCK11 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 사용 가능. Human, Mouse, Rat 반응성. Affinity chromatography로 정제, PBS/glycerol buffer에 보관. 세포 골격 조절 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DOCK11 (Accession Q5JSL3), corresponding to amino acid residues R1325–S1375 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853111 |
Product Specific Information
Antibody detects endogenous levels of total DOCK11.
Target Information
Small GTPases of the Rho family (Rho, Rac, and Cdc42) are key regulators of actin cytoskeleton organization and various cellular processes.
DOCK11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins, mainly expressed in peripheral blood leukocytes.
DOCK11 functions as a guanine nucleotide exchange factor (GEF) that binds and activates Cdc42 by exchanging bound GDP for free GTP.
Cdc42 mediates cell polarity, gene expression, cell cycle progression, and cell-cell contacts.
Similar to other DOCK family members, DOCK11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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