Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI2F6), TrueMAB

Applications and Tested Dilutions

Product Specifications

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from APCs. PD-1 binds ligands PDL-1 and PDL-2, and upon binding, inhibits immune activation in the absence of “danger signals” such as LPS. PD-1 deficiency in mice leads to hyperactivated immune systems and autoimmune conditions. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.