Thermo Fisher Scientific AGR2 Monoclonal Antibody (OTI3B5), TrueMAB
AGR2 단백질을 인식하는 마우스 모노클로날 항체로, Western blot 및 파라핀 포매 조직 IHC에 적합. Human, Mouse, Rat 반응성. 동결건조 형태로 제공되며, PBS 기반 완충액에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 21–175 of human AGR2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
AGR2 (Anterior Gradient Protein 2) and AGR3 belong to the anterior gradient homolog family. These secreted cytoplasmic proteins are involved in metastasis induction and p53 tumor suppressor inhibition.
They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumors.
AGR2 is ubiquitously expressed and upregulated in prostate, breast, lung, renal, and endometrial carcinomas.
Its expression is positively correlated with estrogen receptor (ER) and negatively correlated with epidermal growth factor receptor (EGFR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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