Thermo Fisher Scientific CD276 Polyclonal Antibody
CD276(B7-H3) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 실험에 사용 가능. Human에 반응하며 Mouse 및 Rat에도 예측 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로, 4°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 484–534 of human CD276 Molecule |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
Target Information
CD276 (B7-H3) is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that induces proliferation of CD4+ and CD8+ T cells, enhances cytotoxic T cell generation, and stimulates interferon gamma production.
Expression can be induced on dendritic cells and monocytes by inflammatory cytokines and is found in peripheral tissues such as heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing.
It has potential therapeutic relevance in regulating immune responses to cancer, particularly with anti-angiogenic therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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