Thermo Fisher Scientific RORB Monoclonal Antibody (OTI1G1)
RORB 단백질을 인식하는 Mouse monoclonal antibody로 Western blot과 IHC(Paraffin)에서 검증됨. Human 시료에 반응하며, 액상 형태로 제공. 고순도 친화 크로마토그래피 정제 및 안정적 보존 용이.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–260 of RORB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725258 |
Target Information
Retinoid-related orphan receptor beta (RORβ), a NR1 thyroid hormone receptor, plays a crucial role in the development and functioning of the central nervous system, including sensory input integration and circadian timing.
Disruption of RORβ in mice causes juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility.
RORβ binds as a monomer to response elements containing the sequence AnnTAGGTCA.
An alternatively spliced isoform, RORβ2, is expressed in the pineal gland and retina, sharing DNA- and ligand-binding domains with the wild-type RORβ but differing in the amino-terminal domain.
RORβ expression has been observed in various regions of the mouse brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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