Thermo Fisher Scientific TNPO3 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human TNPO3

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2665269

Product Specific Information

Immunogen sequence: RSLDSFLLSPE AAVGLLKGTA LVLARLPLDK ITECLSELCS VQVMALKKLL SQEPSNGISS DPTVFLDRLA VIFRHTNPIV ENGQTHPCQK VIQEIWPVLS ETLNKHRAD

Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.

Target Information

TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.