Thermo Fisher Scientific CD44 Monoclonal Antibody (KM81)

Applications

Product Specifications

Additional Formats

• Biotin
• FITC
• PE
• Request custom conjugation

Product Specific Information

• MA1-70080 detects CD44 in mouse samples.
• Successfully used in flow cytometry procedures.
• Immunogen: bone marrow derived stromal cells (clone BMS2).
• Molecular weight of CD44: 95 kDa.
• Store at 4°C short term; -20°C long term, avoiding freeze-thaw cycles.

Target Information

CD44 is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms exist, including CD44H, the predominant form in normal tissues.
CD44 functions as a receptor for hyaluronic acid (HA) and plays roles in cell-cell interactions, adhesion, and migration. It contributes to lymphocyte activation, recirculation, and homing, and may be up-regulated in certain carcinomas associated with metastatic potential.
CD44 expression is found in hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia of keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, while peripheral B and T cells can upregulate CD44 expression upon stimulation.
Transcripts undergo complex alternative splicing, producing many distinct isoforms that contribute to CD44’s structural and functional diversity.
Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be related to tumor metastasis formation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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