Thermo Fisher Scientific EEA1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human EEA1, suitable for WB and IP applications. Recognizes region 175–225 of EEA1. Supplied as a liquid, unconjugated form at 0.20 mg/mL concentration. Stored at 4°C and shipped on wet ice. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 and 225 of human early endosome antigen 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Early endosomal antigen 1 (EEA1) is a 162 kDa membrane-bound protein specific to the early endosome and essential for fusion between early endocytic vesicles. Early endosomes fuse with endocytic vesicles to redistribute extracellular compounds to alternate destinations. Zinc-finger-like domains are located in the amino and carboxyl-terminal regions of EEA1, with the carboxyl-terminal domain being conserved among other non-nuclear proteins involved in intracellular trafficking. This domain binds zinc and is critical for the intracellular localization of EEA1. Membrane association of EEA1 depends on phosphatidyl 3-kinase activity; inhibitors cause EEA1 to dissociate from early endosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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