Thermo Fisher Scientific C7orf60 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
QERKLEQEKLS GVVKSVHRRL RKKYREVGDF DKIWREHCED EETLCEYAVA MKNLADNHWA KTCEGEGRIE WCCSVCREYF Q

Highest antigen sequence identity to the following orthologs:

• Mouse: 99%
• Rat: 38%

Target Information

S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071).
Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disruption of interaction with GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling (PubMed:29123071).
Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting association with GATOR1 and KICSTOR, leading to inhibition of mTORC1 signaling (PubMed:29123071).
Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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