Thermo Fisher Scientific C7orf60 Polyclonal Antibody
Human C7orf60 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF에 사용 가능하며 고순도의 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보존되며 mTORC1 신호 조절 관련 연구에 적합.
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- PA565637
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- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human C7orf60 (Recombinant protein control fragment: Product #RP-106306) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663410 |
Product Specific Information
Immunogen sequence:
QERKLEQEKLS GVVKSVHRRL RKKYREVGDF DKIWREHCED EETLCEYAVA MKNLADNHWA KTCEGEGRIE WCCSVCREYF Q
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 38%
Target Information
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071).
Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disruption of interaction with GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling (PubMed:29123071).
Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting association with GATOR1 and KICSTOR, leading to inhibition of mTORC1 signaling (PubMed:29123071).
Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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