Thermo Fisher Scientific F1A alpha Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 368-627 of human FEM1B (NP_0561371) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:F1A alpha,uniProtId:Q9UK73-1,ncbiNodeId:9606,antigenRange:368-627,antigenLength:627,antigenImageFileName:PA5-88764_F1A_alpha_Q9UK73-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88764_F1A_alpha_Q9UK73-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.56 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805114

Product Specific Information

Immunogen sequence: LHALHLRQKG NRNTHKDLLR FAQVFSQMIH LNETVKAPDI ECVLRCSVLE IEQSMNRVKN ISDADVHNAM DNYECNLYTF LYLVCISTKT QCSEEDQCKI NKQIYNLIHL DPRTREGFTL LHLAVNSNTP VDDFHTNDVC SFPNALVTKL LLDCGAEVNA VDNEGNSALH IIVQYNRPIS DFLTLHSIII SLVEAGAHTD MTNKQNKTPL DKSTTGVSEI LLKTQMKMSL KCLAARAVRA NDINYQDQIP RTLEEFVGFH; Positive Samples: A-549; Cellular Location: Cytoplasm, Nucleus

Target Information

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1-b. F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.