Thermo Fisher Scientific F1A alpha Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
LHALHLRQKG NRNTHKDLLR FAQVFSQMIH LNETVKAPDI ECVLRCSVLE IEQSMNRVKN ISDADVHNAM DNYECNLYTF LYLVCISTKT QCSEEDQCKI NKQIYNLIHL DPRTREGFTL LHLAVNSNTP VDDFHTNDVC SFPNALVTKL LLDCGAEVNA VDNEGNSALH IIVQYNRPIS DFLTLHSIII SLVEAGAHTD MTNKQNKTPL DKSTTGVSEI LLKTQMKMSL KCLAARAVRA NDINYQDQIP RTLEEFVGFH

Positive Samples: A-549
Cellular Location: Cytoplasm, Nucleus

Target Information

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha (FEM1-b). F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1.
FEM-1/F1Aalpha is cleaved by CED-3 and caspase, associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis.
F1Aalpha is therefore a novel member of the death receptor-associated protein family that mediates apoptosis. F1Aalpha is expressed in various human and mouse tissues.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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