Thermo Fisher Scientific F1A alpha Polyclonal Antibody
Rabbit polyclonal antibody targeting human F1A alpha (FEM1B), validated for WB and ELISA. Recombinant immunogen (aa 368–627), affinity purified, liquid form. Suitable for apoptosis-related research; store at -20°C.
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- PA588764
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 368–627 of human FEM1B (NP_0561371) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.56 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805114 |
Product Specific Information
Immunogen sequence:
LHALHLRQKG NRNTHKDLLR FAQVFSQMIH LNETVKAPDI ECVLRCSVLE IEQSMNRVKN ISDADVHNAM DNYECNLYTF LYLVCISTKT QCSEEDQCKI NKQIYNLIHL DPRTREGFTL LHLAVNSNTP VDDFHTNDVC SFPNALVTKL LLDCGAEVNA VDNEGNSALH IIVQYNRPIS DFLTLHSIII SLVEAGAHTD MTNKQNKTPL DKSTTGVSEI LLKTQMKMSL KCLAARAVRA NDINYQDQIP RTLEEFVGFH
Positive Samples: A-549
Cellular Location: Cytoplasm, Nucleus
Target Information
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha (FEM1-b). F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1.
FEM-1/F1Aalpha is cleaved by CED-3 and caspase, associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis.
F1Aalpha is therefore a novel member of the death receptor-associated protein family that mediates apoptosis. F1Aalpha is expressed in various human and mouse tissues.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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