Thermo Fisher Scientific Kir2.2 (KCNJ12) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500

-

Product Specifications

Species Reactivity

Human

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human KCNJ12. Recombinant protein control fragment (Product #RP-91128). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Kir2.2 (KCNJ12),uniProtId:Q14500-1,ncbiNodeId:9606,antigenRange:356-433,antigenLength:433,antigenImageFileName:PA5-55485_Kir2.2_KCNJ12_Q14500-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55485_Kir2.2_KCNJ12_Q14500-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642933

Product Specific Information

Immunogen sequence: RCSAKDLVEN KFLLPSANSF CYENELAFLS RDEEDEADGD QDGRSRDGLS PQARHDFDRL QAGGGVLEQR PYRRESEI

Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 81%.

Target Information

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.