Thermo Fisher Scientific KLC1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

Immunogen sequence:
EEAAMRSRKQ GLDNVHKQRV AEVLNDPENM EKRRSRESLN VDVVKYESGP DGGEEVSMSV EWNG

Sequence identity to orthologs:

• Mouse: 97%
• Rat: 97%

Target Information

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends.
The heavy chains provide the motor activity, while the light chains bind to various cargos.
This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding cargos such as vesicles, mitochondria, and the Golgi complex.
Thus, kinesin light chains function as adapter molecules and not motors per se.
Although previously named kinesin 2, this gene is not a member of the kinesin-2/kinesin heavy chain subfamily of kinesin motor proteins.
Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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