Thermo Fisher Scientific Phospho-SMC1 (Ser957) Polyclonal Antibody
Phospho-SMC1 (Ser957) 폴리클로날 항체로, 인간 SMC1의 Ser957 인산화 부위를 인식합니다. Western blot 및 IHC(P) 검증 완료. 세포 분열과 염색체 응집 연구에 적합하며, 고품질 Rabbit IgG 형식의 액상 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human SMC1 around the phosphorylation site of Ser957 (G-S-SP-Q-G) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556250 |
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair, and global transcriptional repression. These proteins are conserved in eukaryotes and are essential for proper mitotic chromosome segregation. The SMC1 and SMC3 proteins form a heterodimeric complex required for metaphase progression and sister chromatid cohesion during mitosis. Mutations in the SMC1 gene can lead to Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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