Thermo Fisher Scientific TRPM4 Polyclonal Antibody
TRPM4 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot에 최적화됨. Human 및 Rat에 반응하며, 0.5 mg/mL 농도의 액상 제품. Affinity chromatography로 정제되어 안정적인 신뢰성 제공. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 0.2–1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of human TRPM4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2689247 |
Product Specific Information
This target displays homology in the following species:
- Cow: 79%
- Dog: 86%
- Guinea Pig: 93%
- Horse: 86%
- Human: 100%
- Mouse: 100%
- Rat: 100%
Target Information
Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization. Activated by increased intracellular Ca²⁺ but impermeable to it. Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization. Plays a central role in cardiomyocytes, neurons, endocrine pancreas cells, kidney epithelial cells, and cochlea hair cells. Participates in T-cell activation by modulating Ca²⁺ oscillations required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries and insulin secretion in pancreatic beta-cells. May contribute to pacemaking and irregular electrical activity under Ca²⁺ overload. Regulates Th1 and Th2 cell motility and cytokine production via calcium signaling and NFATC1 localization. Enhances cell proliferation through β-catenin signaling pathway up-regulation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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