Thermo Fisher Scientific GADD45A Polyclonal Antibody
GADD45A 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성을 가지며, 고순도의 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GADD45A (Accession P24522), corresponding to amino acid residues M1–A43 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854557 |
Product Specific Information
This antibody detects endogenous levels of total GADD45A.
Target Information
GADD45 alpha, beta, and gamma are evolutionarily conserved nuclear proteins functioning as stress sensors for cellular and environmental damage. They are required for activation of the G2/M checkpoint induced by UV radiation or alkylating agents. GADD45-induced G2/M checkpoint regulation occurs through inactivation of Cdc2-cyclin B1 kinase. GADD45 forms a complex with p21 and Cdc2, potentially serving as a core for interaction with other cell cycle regulators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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