Thermo Fisher Scientific cGKI Monoclonal Antibody (OTI9A4)
cGKI 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, ICC/IF, Flow cytometry에 사용 가능. Human 시료 반응성. Affinity chromatography로 정제된 1 mg/mL 액상 형태. PRKG1 단백질 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9A4 |
| Immunogen | Full length human recombinant protein of PRKG1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724127 |
Target Information
PRKG1 is a cGMP-dependent serine/threonine kinase that plays an important role in the relaxation of vascular smooth muscle and inhibition of platelet aggregation. It regulates cardiovascular and neuronal functions, smooth muscle tone, and cell growth. This gene is strongly expressed in smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Iα and Iβ share identical cGMP-binding and catalytic domains but differ in leucine/isoleucine zipper and autoinhibitory sequences, leading to differences in dimerization substrates and kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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