Thermo Fisher Scientific CD38 (ADP Ribosyl Cyclase I) Recombinant Rabbit Monoclonal Antibody (CD38, 6448R)

Applications

• Western Blot (WB): 1–2 µg/mL
• Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL

Product Specifications

Product Specific Information

For immunohistochemistry (PFA-fixed):
Incubate antibody for 30 minutes at room temperature. Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase, or as a cell surface receptor.

Antibodies to CD38 are useful for:

• Subtyping of lymphomas and leukemias
• Detection of plasma cells (e.g., identification of myelomas)
• Marker for activated B and T cells

CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.