Thermo Fisher Scientific HDAC8 Polyclonal Antibody
HDAC8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인체 유래 단백질에 반응하며, 액상 형태로 제공됩니다. 고순도의 정제 항체로, 장기 보관 시 -20°C에서 안정적입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 1–30 amino acids from the N-terminal region of human HDAC8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2116920 |
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation, largely influenced by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histones causes conformational changes that increase DNA accessibility to transcription factors. Conversely, histone deacetylation is associated with transcriptional silencing.
Several mammalian proteins act as nuclear histone acetylases, including GCN5, PCAF, p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase homologous to other HDACs but with distinct tissue distribution. HDAC8 is localized to the nucleus and plays a role in tissue development and cancer etiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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