Thermo Fisher Scientific SIX5 Polyclonal Antibody
SIX5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. Human 및 Mouse 반응성. Affinity chromatography로 정제된 액상형 항체이며, -20°C에서 보관. 연구용으로 적합.
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- PA5101644
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SIX5 (Accession Q8N196), corresponding to amino acid residues A611–A661 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851078 |
Product Specific Information
Antibody detects endogenous levels of total SIX5.
Target Information
Six5 (homeobox protein SIX5), also known as SIX5, BOR2, or DMAHP, is a transcription factor expressed in various structures of the adult eye. It localizes to the cytoplasm in early development and to the nucleus in later stages, playing a role in organogenesis and retinal maintenance.
Six5 binds the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in myogenin and IGFBP5 promoters, regulating transcription. It interacts with DACH1 and is co-activated by EYA proteins.
Defects in the Six5 gene cause branchiooto-renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, deep overbite, and myopia. Two isoforms exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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