Thermo Fisher Scientific UFD1L Monoclonal Antibody (OTI7C9), TrueMAB
UFD1L 단백질을 인식하는 Mouse monoclonal 항체로 Western blot 및 IHC(P) 검증 완료. 고순도 Affinity chromatography 정제, 1 mg/mL 농도. PBS, BSA, glycerol 포함 buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7C9 |
| Immunogen | Full length human recombinant protein of human UFD1L produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, leading to their degradation by the 26S proteasome. Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or through the Ub-fusion degradation (UFD) pathway. The UFD1 protein, first identified in S. cerevisiae, has a human homolog known as UFD1L. UFD1 attenuates degradation of Ub-fusions with amino acid substitutions at Gly76 by promoting selective multiubiquitination. Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting involvement in developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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