Thermo Fisher Scientific Human PLEKHO1 Synthetic Peptide
Human CKIP1(CKIP1) C-말단 18개 아미노산 서열 기반 합성 펩타이드로, Thermo Fisher Scientific의 PA5-20827 항체 블로킹 용도로 사용 가능. 정제된 액상 형태이며 PBS(pH 7.2, 0.1% BSA, 0.02% sodium azide)에 보관. 연구용으로만 사용.
- 카탈로그번호
- PEP0941
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the carboxy terminus of human CKIP1.
PEP-0941 can be used as a blocking peptide with polyclonal antibody PA5-20827.
Target Information
CKIP1 was identified through a yeast-two hybrid screening as a protein interacting with one of the two catalytic subunits of the casein kinase 2 complex.
CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and plasma membrane, interacting with CK2alpha but not CK2alpha’. It plays a role in targeting CK2alpha to specific cellular locations and is implicated in muscle differentiation, cell morphology, and actin cytoskeleton regulation.
Additionally, CKIP1 interacts with ATM, an upstream kinase of p53, recruiting nuclear ATM to the plasma membrane and potentially regulating ATM function. CKIP1 can form a complex with AKT, leading to down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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