Thermo Fisher Scientific CCM2 Polyclonal Antibody
Human CCM2 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에서 0.25–2 µg/mL 농도로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 40%, sodium azide 0.02%) 용액 상태로 제공. 세포골격 및 세포 간 상호작용 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CCM2. Recombinant protein control fragment (Product #RP-107456). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857017 |
Product Specific Information
Immunogen sequence:
KDSQHFENFL ETIGVKDGRG IITDSFGRHR RALSTTSSST TNGNRATGSS DDRSAPSEGD EWDRMISDIS SDVEALGCSM DQDS
Target Information
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade.
The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation.
It is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells.
Mutations in this gene result in cerebral cavernous malformations.
Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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