Thermo Fisher Scientific GUK1 Monoclonal Antibody (OTI4A8), TrueMAB
GUK1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, Flow Cytometry에 적합. HEK293T 세포에서 발현된 full-length human GUK1 단백질을 면역원으로 사용. 고순도 Affinity chromatography 정제, 액상 형태로 공급.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific GUK1 Monoclonal Antibody (OTI4A8), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A8 |
| Immunogen | Full length human recombinant protein of human GUK1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.47 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Guanylate kinase (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP.
In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast), and vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids.
GK has been shown to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.
Proteins containing one or more copies of the DHR domain, an SH3 domain, as well as a C-terminal GK-like domain, are collectively termed MAGUKs (membrane-associated guanylate kinase homologs) and include:
- Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1)
- Mammalian tight junction protein Zo-1
- Synaptic proteins interacting with NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1, SAP102)
- Vertebrate 55 kDa erythrocyte membrane protein (p55)
- C. elegans protein lin-2
- Rat protein CASK
- Human proteins DLG2 and DLG3
There is an ATP-binding site (P-loop) in the N-terminal section of GK, which is not conserved in the GK-like domain of the above proteins. However, these proteins retain the residues known in GK to be involved in the binding of MP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.