Thermo Fisher Scientific DLAT Polyclonal Antibody
DLAT 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, Flow cytometry에 적합하며, 고순도 Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 인간 DLAT C-말단 펩타이드(aa 579-607)를 면역원으로 사용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 579–607 amino acids from the C-terminal region of human DLAT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542760 |
Target Information
DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product, dihydrolipoamide acetyltransferase, transfers acetyl groups formed by oxidative decarboxylation of pyruvate to coenzyme A.
Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies, present in nearly 95% of patients with primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed, leading to cirrhosis and liver failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(PA5-25260_DLAT_P10515-1_Rabbit.svg 및 PA5-25260_DLAT_P10515-1_Rabbit_PDP.jpeg)
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