Thermo Fisher Scientific Dematin Polyclonal Antibody
Human Dematin 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:200–1:500 희석 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Dematin. Recombinant protein control fragment (Product # RP-93854) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640509 |
Product Specific Information
Immunogen sequence:
SKSSSLPAYG RTTLSRLQST EFSPSGSETG SPGLQNGEGQ RGRMDRGNSL PCVLEQKIYP YEMLVVTNKG RTKLPP
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 47%
Target Information
The protein encoded by this gene is an actin-binding and bundling protein that plays a structural role in erythrocytes by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner.
This protein contains a core domain in the N-terminus and a headpiece domain in the C-terminus that binds F-actin.
When purified from erythrocytes, it exists as a trimer composed of two 48 kDa polypeptides and one 52 kDa polypeptide.
The subunit variation arises from alternative splicing in the 3′ coding region.
Disruption of this gene has been correlated with autosomal dominant Marie Unna hereditary hypotrichosis, and loss of heterozygosity is implicated in prostate cancer progression.
Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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