Thermo Fisher Scientific TRAIL Polyclonal Antibody
TRAIL 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, ICC, ELISA 등 다양한 응용에 적합하며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다.
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Thermo Fisher Scientific TRAIL Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TRAIL (amino acids 185–281) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TRAIL (TNF-related apoptosis-inducing ligand) is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It preferentially induces apoptosis in transformed and tumor cells while sparing normal cells, despite widespread expression in normal tissues. TRAIL interacts with several TNF receptor superfamily members, including:
- TNFRSF10A/TRAILR1 (DR4)
- TNFRSF10B/TRAILR2 (DR5)
- TNFRSF10C/TRAILR3 (DcR1)
- TNFRSF10D/TRAILR4 (DcR2)
- TNFRSF11B/OPG
Binding to decoy receptors (TRAILR3, TRAILR4, OPG) modulates TRAIL activity by preventing apoptosis induction. TRAIL signaling triggers activation of MAPK8/JNK, caspase 8, and caspase 3, leading to programmed cell death and NF-κB activation in various tissues.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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