Thermo Fisher Scientific PIK3R6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
PAAPVTDHTC LNVNVTEVVK SSNLAGKSFS TVTNTFRTNN IQIQSRDQRL LTLSLDKDDQ RTFRDVVRFE VAPCPEPCSG AQKSKAPWLN LHGQQEVEAI KAKPKP

Highest antigen sequence identity to the following orthologs:

• Mouse: 71%
• Rat: 67%

Target Information

p87PIKAP (p87 PI3K adapter protein), also known as PIK3R6 (phosphoinositide-3-kinase, regulatory subunit 6), p84, or HsT41028, is a 754 amino acid cytoplasmic protein that functions as a regulatory subunit of the PI 3-kinase p110 complex.
It is expressed in heart, dendritic cells, macrophages, and neutrophils, where it drives PI 3-kinase p110 activation, interacts with PDE3B, and facilitates scaffolding interactions.

The gene encoding p87PIKAP maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes more than 1,200 genes. Two key tumor suppressor genes associated with chromosome 17 are p53 and BRCA1.

• p53 maintains genomic integrity by regulating DNA repair and apoptosis.
• BRCA1 is involved in DNA repair and is linked to early-onset breast and ovarian cancers, as well as cancers of the colon, prostate, and fallopian tubes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.