Thermo Fisher Scientific RFWD3 Polyclonal Antibody
인간 RFWD3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunocytochemistry에 사용 가능. DNA 손상 복구 관련 연구에 적합하며, 고순도의 Affinity chromatography로 정제됨. PBS/glycerol 완충액에 보관되며 -20°C에서 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RFWD3 (Accession Q6PCD5), corresponding to amino acid residues S119–T169 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2851285 |
Product Specific Information
Antibody detects endogenous levels of total RFWD3.
Target Information
E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2, and RPA3 subunits) and RAD51 at stalled replication forks, leading to their removal from DNA damage sites and promoting homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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