Thermo Fisher Scientific ADAMTS4 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1.0 µg/mL
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Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%

Target Information

This gene encodes a member of the ADAMTS protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
The enzyme encoded by this gene lacks a C-terminal TS motif and is responsible for the degradation of aggrecan (a major proteoglycan of cartilage) and brevican (a brain-specific extracellular matrix protein). These cleavage activities suggest key roles in arthritic disease and central nervous system function, potentially in glioma progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.