Thermo Fisher Scientific Human RXRA, Ligand Binding Domain, GST Tag Recombinant Protein

Thermo Fisher Scientific Human RXRA, Ligand Binding Domain, GST Tag Recombinant Protein

Applications

• Ligand Binding Assay (LBA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

Retinoid X receptor alpha, ligand binding domain (RXRA-LBD) is a 56.67 kDa recombinant human protein (amino acids 204–462) expressed as a GST fusion protein in baculovirus-infected insect cells.
RXRA-LBD was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies.

Functional Assay:
Functionally confirmed in a LanthaScreen™ TR-FRET coactivator assay to ensure performance.

Target Information

Retinoic Acid (RA), the active metabolite of vitamin A, plays a major role in regulating the transition of proliferating precursor cells (such as carcinoma and neuronal precursors) to postmitotic differentiated cells.
The Retinoid X Receptor (RXR) family—comprising RXR alpha, beta, and gamma—preferentially binds 9-cis-RA and regulates gene transcription by forming heterodimers with retinoic acid receptors (RARs).
RAs are implicated in neuronal development, synaptic plasticity, learning, memory, and may have therapeutic potential in cervical cancer.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.