Thermo Fisher Scientific VNN1 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal VNN1 항체로 Western Blot, IHC, ICC/IF에 사용 가능. 합성 펩타이드 기반 면역원으로 제작, 고순도 친화 크로마토그래피 정제. 액상 형태, -20°C 보관, 연구용 전용.
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- PA5100085
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- pk
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Thermo Fisher Scientific VNN1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human VNN1 (Accession O95497), amino acid residues L400–G450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815615 |
Product Specific Information
This antibody detects endogenous levels of total VNN1.
Target Information
Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes. The GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells. Vanin-1 acts as a pantetheinase enzyme, catalyzing the hydrolysis of pantetheine for vitamin B5 recycling and generating cysteamine, a potent antioxidant. It serves as a membrane-bound source of cysteamine under normal physiological conditions. In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, aiding cell migration.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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