Thermo Fisher Scientific ZO-1 Polyclonal Antibody
ZO-1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. Human, Mouse, Rat에 반응하며, 고순도 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific ZO-1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 4 Publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | 1 Publication |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 1 Publication |
| Immunocytochemistry (ICC/IF) | 1:250–1:1,000 | 9 Publications |
| Flow Cytometry (Flow) | - | 1 Publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence from the N-terminal region of human ZO-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.1% Sodium Azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533048 |
Target Information
ZO-1 forms complexes with either ZO-2 or ZO-3, and these proteins can associate with claudin, occludin, and F-actin at tight junction strands, linking the actin cytoskeleton to the tight junction.
ZO-1 expression is reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, whereas ZO-1 is also expressed at cardiac myocyte junctions.
ZO-1 may play a role in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene.
Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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