Thermo Fisher Scientific NALP12 Monoclonal Antibody (4B9)
Human NALP12 단백질을 인식하는 Mouse IgG2a 단클론 항체. Western blot 및 ELISA에 적합하며, 염증 반응 조절 연구에 활용 가능. PBS buffer에 보관되며, 방부제 무첨가. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B9 |
| Immunogen | NALP12 (AAH28069, 1–110 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MLRTAGRDGL CRLSTYLEEL EAVELKKFKL YLGTATELGE GKIPWGSMEK AGPLEMAQLL ITHFGPEEAW RLALSTFERI NRKDLWERGQ REDLVRDTPP GGPSSLGNQS
Target Information
NALP proteins are cytoplasmic proteins forming a subfamily within the CATERPILLER family, playing a key role in cell proliferation and reproduction.
NALP12 (Monarch-1) contains:
- C-terminal leucine-rich repeat (LRR) region
- N-terminal Pyrin domain (PYD)
- NACHT domain and NACHT-associated domain
NALP12 acts as an attenuating factor of inflammation by suppressing NF-kappa-B activation through TLR-signaling molecules (MyD88, IRAK-1, TRAF6, RIPK1) in activated monocytes.
Mutations in NALP12 are associated with hereditary periodic fever syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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