Thermo Fisher Scientific WNK1 Polyclonal Antibody
WNK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인체 및 비인간 영장류 반응성. IHC(P)에서 7 µg/mL로 사용 가능. 전해질 항상성 및 혈압 조절 연구에 적합. 항원 친화 크로마토그래피로 정제된 고품질 항체.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 7 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from internal region of human WNK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550570 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Elephant, Panda (95%); Bat, Rabbit, Pig (89%); Mouse, Rat, Hamster (84%).
For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
WNK1 serine/threonine kinase is a member of the WNK subfamily. It may regulate blood pressure by controlling sodium and chloride ion transport. Mutations in WNK1 are associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II.
WNK1 plays a key role in electrolyte homeostasis, cell signaling, survival, and proliferation. It acts as both activator and inhibitor of sodium-coupled and potassium-coupled chloride cotransporters, respectively.
Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. Localizes to the distal nephron segment involved in salt, potassium, and pH homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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