Thermo Fisher Scientific CDKL2 Monoclonal Antibody (OTI2D8), TrueMAB
인간 CDKL2 단백질(aa 291-493)을 항원으로 제작된 Mouse IgG2a 단일클론 항체. Western blot에 1:2,000 희석으로 사용 가능. 비결합형 액상 형태로 1 mg/mL 농도. PBS, BSA, 글리세롤 완충액에 보관하며 -20°C에서 안정적 저장 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D8 |
| Immunogen | Human recombinant protein fragment (aa 291–493 of human CDKL2) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK1 and ERK2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif.
The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain, and lung.
KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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