Thermo Fisher Scientific Roquin Polyclonal Antibody
Roquin 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 4°C 보관, 연구용 전용 제품입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1075 and the C-terminus (residue 1133) of Human Ring Finger and CCCH-type finder domains 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING-type ubiquitin ligase protein family. The M199R mutation in RC3H1 leads to excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, which exhibit high IL-21 levels and autoantibody titers. Complete loss of RC3H1 causes early death and immune deregulation, but not autoimmunity, suggesting that the mutant form is more disruptive than its absence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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