Thermo Fisher Scientific Leptin Receptor Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,800–1:2,200
• View 1 publication

Product Specifications

Product Specific Information

PA1-28843 detects Leptin receptor from mouse samples.

Target Information

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily and plays a crucial role in mammalian body weight homeostasis and energy balance. Activation by leptin triggers downstream signaling through the JAK/STAT pathway.
Leptin can homo-dimerize OB-R extracellular domains, initiating intracellular signaling via OB-R dimerization.
Multiple isoforms of OB-R exist, differing in length and signaling capabilities.
RNA transcripts encoding the OB-R long form have been found in the choroid plexus and hypothalamus, proposed as centers for satiety and energy expenditure.
Mutations in mouse OB-R (db) or leptin (ob) genes cause early-onset obesity and metabolic abnormalities such as hypercorticoidemia, hyperinsulinemia, insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate in brown adipose tissue, and increased white adipose tissue.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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