Thermo Fisher Scientific Aldo-keto Reductase Family 1 Member B1 (Adrenal Marker) Recombinant Rabbit Monoclonal Antibody (AKR1B1/7009R)
Recombinant rabbit monoclonal antibody targeting AKR1B1, an adrenal marker. Suitable for WB, IHC(P), and IE applications. High purity (Protein A/G) and stable for 24 months. Useful for studying diabetic complications and adrenal tumorigenesis.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AKR1B1/7009R |
| Immunogen | Recombinant human full-length AKR1B1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: MOLT4, Jurkat, or Raji cells; human kidney or colon carcinoma.
- Cellular Localization: Cytoplasm
Specificity Comments:
AKR1B1 (aldose reductase) is a member of the aldo/keto reductase superfamily, comprising over 40 known enzymes and proteins. It catalyzes the reduction of aldehydes, including the aldehyde form of glucose, and is implicated in diabetic complications by converting glucose to sorbitol. Decreased expression has been observed in adrenocortical cancer, suggesting a role in adrenal tumorigenesis. AKR1B1 may serve as a malignancy marker for adrenal tumor diagnosis.
Target Information
Catalyzes the NADPH-dependent reduction of carbonyl-containing compounds to their corresponding alcohols, exhibiting broad catalytic efficiency.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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