Thermo Fisher Scientific GPR149 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

This gene encodes a seven-transmembrane G protein-coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors, which is important for efficient G protein-coupled signal transduction.
Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle but show enhanced fertility and ovulation.
All GPCRs share a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, generating second messengers that mediate a broad range of cellular and physiological processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.