Thermo Fisher Scientific ALKBH7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ALKBH7. Recombinant protein control fragment (Product #RP-96561). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ALKBH7,uniProtId:Q9BT30-1,ncbiNodeId:9606,antigenRange:100-188,antigenLength:221,antigenImageFileName:PA5-58959_ALKBH7_Q9BT30-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58959_ALKBH7_Q9BT30-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2637870

Product Specific Information

Immunogen sequence: GQTLLSSVHV LDLEARGYIK PHVDSIKFCG ATIAGLSLLS PSVMRLVHTQ EPGEWLELLL EPGSLYILRG SARYDFSHEI LRDEESFFG

Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 91%.

Target Information

ALKBH7 (alkB, alkylation repair homolog 7), also known as SPATA11, is a 221 amino acid protein belonging to the alkB family. ALKBH7 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. ALKBH7 is encoded by a gene located on human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognizedfor having the greatest gene density of the human chromosomes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.