Thermo Fisher Scientific CD27 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. TNF superfamily members regulate cell proliferation and death. CD27 and its ligand CD70 are mainly expressed in lymphocytes. High CD27 expression depends on proper antigen receptor ligation, while CD70 requires co-stimulatory or pro-inflammatory signals.

CD27 exists as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and certain B cells. T cell activation via the TCR-CD3 complex increases CD27 expression and releases its soluble 28–32 kDa form (sCD27), found in plasma, urine, or spinal fluid. Soluble CD27 serves as a prognostic marker for acute and chronic B cell malignancies.

RgpA, a cysteine proteinase, degrades CD27 and counteracts T cell activation mediated by CD27–CD70 interaction. CD27-binding protein (SIVA), a proapoptotic molecule, binds CD27 and plays a role in CD27-induced apoptosis. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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