Thermo Fisher Scientific STAT4 Monoclonal Antibody (OTI 4H4), TrueMAB
인간 STAT4 단백질을 타깃으로 하는 마우스 단클론 항체로, Western blot 및 IHC(Paraffin)에 적합합니다. TrueMAB 기술 기반으로 높은 특이성과 재현성을 제공하며, IL-12 관련 신호전달 연구에 활용됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI 4H4 |
| Immunogen | Full length human recombinant protein of human STAT4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 can be tyrosine phosphorylated by Jak1 or Jak2 and forms homo- and heterodimers with other STAT family members. Tyrosine-phosphorylated STAT4 binds the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.
STAT4 expression is restricted to the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which is essential for T-cell independent induction of IFN-gamma and Th1 development. STAT4-deficient mice show impaired IL-12–mediated Th1 cell development and enhanced Th2 differentiation. In viral infection, IFN-α/β activation of STAT4 is required for IFN-γ production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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