Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (LN-3, HLA-DRB/1067)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

-

Immunohistochemistry (PFA fixed) (IHC (PFA))

0.25-0.5 µg/mL

-

Immunocytochemistry (ICC/IF)

1-2 µg/mL

-

Flow Cytometry (Flow)

1-2 µg/10^6 cells

-

Product Specifications

Species Reactivity

Human, Non-human primate

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

LN-3, HLA-DRB/1067

Immunogen

Activated human peripheral blood mononuclear cells (LN-3 & HLA-DRB/1067) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HLA-DR beta,uniProtId:P01911-1,ncbiNodeId:9606,antigenRange:1-266,antigenLength:266,antigenImageFileName:3123-MSM5-P0_HLA-DR_beta_P01911-1_House_mouse.svg,antigenImageFileNamePDP:3123-MSM5-P0_HLA-DR_beta_P01911-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4° C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

HLA-DR beta refers to the beta chain of the HLA-DR protein complex, which is a member of the human leukocyte antigen (HLA) class II molecule. The HLA-DR beta chain is encoded by the HLA-DRB gene. HLA-DR beta is primarily on the surface of antigen-presenting cells, including dendritic cells, macrophages, and B cells. These cells play a crucial role in the immune system by capturing, processing, and presenting antigens to T cells for immune recognition. HLA-DR beta is a critical component of the immune system, facilitating the recognition and response to extracellular antigens. Its function in presenting antigenic peptides to CD4+ T cells plays a vital role in the activation of adaptive immune responses. HLA-DR beta consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain contains the peptide-binding groove, which interacts with antigenic peptides. The transmembrane domain anchors the HLA-DR beta chain to the cell membrane, while the cytoplasmic tail is involved in intracellular signaling events.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.