Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (LN-3, HLA-DRB/1067)
Thermo Fisher Scientific의 HLA-DRB (MHC II) Monoclonal Antibody는 인간 및 비인간 영장류 시료에 반응하며, 다양한 면역학적 분석(WB, IHC, ICC, Flow)에 적합합니다. LN-3, HLA-DRB/1067 클론 기반으로 제작된 고순도 단일클론 항체로, 4°C에서 안정적으로 보관 가능합니다.
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Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (LN-3, HLA-DRB/1067)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.25–0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LN-3, HLA-DRB/1067 |
| Immunogen | Activated human peripheral blood mononuclear cells (LN-3 & HLA-DRB/1067) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
HLA-DR beta refers to the beta chain of the HLA-DR protein complex, a member of the human leukocyte antigen (HLA) class II molecule family.
The HLA-DR beta chain, encoded by the HLA-DRB gene, is primarily expressed on the surface of antigen-presenting cells such as dendritic cells, macrophages, and B cells.
These cells play a crucial role in immune defense by capturing, processing, and presenting antigens to T cells for immune recognition.
HLA-DR beta contains:
- Extracellular domain: Peptide-binding groove interacting with antigenic peptides
- Transmembrane domain: Anchors the chain to the cell membrane
- Cytoplasmic tail: Involved in intracellular signaling
HLA and MHC antibodies are essential tools in Immunopeptidomics, enabling identification and characterization of neoantigens via LC-MS/MS analysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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