Thermo Fisher Scientific Optineurin Polyclonal Antibody
Optineurin 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC에 적합. 인간 시료 반응성 확인됨. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Optineurin. Recombinant protein control fragment (Product #RP-101058). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644994 |
Product Specific Information
Immunogen sequence:
LGIVSELQLK LNSSGSSEDS FVEIRMAEGE AEGSVKEIKH SPGPTRTVST GTALSKYRSR SADGAKNYFE HEELTVSQLL LCLREGNQKV ERLEVALKEA KERVSDFEKK TSNRSEIETQ TEGSTEKEND EEKG
Highest antigen sequence identity to the following orthologs:
- Mouse: 64%
- Rat: 68%
Target Information
This gene encodes the coiled-coil containing protein Optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open-angle glaucoma. It interacts with adenovirus E3-14.7K protein and may utilize TNF-alpha or Fas-ligand pathways to mediate apoptosis, inflammation, or vasoconstriction.
Optineurin is also involved in cellular morphogenesis, membrane and vesicle trafficking, and transcription activation through interactions with RAB8, huntingtin, and transcription factor IIIA proteins.
Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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